| Year | Title | Role | Notes |
|---|
| 1986 | Amazing Stories: Book Three | Casey | Episode: "No Day at the Beach" |
| 1996 | Friends | Ryan | Episode: "The One with the Chicken Pox" |
| 1999 | Sugar Hill | Matt | unsold pilot |
| 2000–2002 | Spin City | Charlie Crawford | Golden Globe Award for Best Actor – Television Series Musical or Comedy (2002)
Nominated – ALMA Award for Outstanding Actor in a Television Series (2001)
Nominated – ALMA Award for Outstanding Actor in a Television Series (2002)
|
| 2003–2011 | Two and a Half Men | Charlie Harper | ALMA Award for Outstanding Actor in a Comedy Television Series (2008)
Nominated – Kids Choice Awards for Favorite Television Actor (2002)
Nominated – Screen Actors Guild Award for Outstanding Performance by a Male Actor in a Comedy Series (2005)
Nominated – Golden Globe Award for Best Actor – Television Series Musical or Comedy (2005)
Nominated – Primetime Emmy Award for Outstanding Lead Actor in a Comedy Series (2006)
Nominated – Golden Globe Award for Best Actor – Television Series Musical or Comedy (2006)
Nominated – Teen Choice Award for Choice TV Actor: Comedy (2008)
Nominated – Primetime Emmy Award for Outstanding Lead Actor in a Comedy Series (2008)
Nominated – Screen Actors Guild Award for Outstanding Performance by a Male Actor in a Comedy Series (2009) |
| 2006 | Overhaulin' | Himself | Episode: "LeMama's Boy" |
| 2008 | The Big Bang Theory | Himself | Episode: "The Griffin Equivalency", cameo appearance |
| 2009 | The Tonight Show with Jay Leno | Himself |
|
| 2009 | Lopez Tonight | Himself |
|
| 2010 | Family Guy | Himself | Episode: "Brian Griffin's House of Payne" |
| 2011 | Drew Carey's Improv-A-Ganza | Himself | Episode 2 (in improv game "Fairy Tale") |
